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Many people find it difficult to obtain a satisfactory level of effects when smoking Salvia divinorum leaf. Usually this is because of insufficient dose, improper smoking technique, or low sensitivity to salvinorin A.
The active principal of Salvia divinorum is a diterpenoid compound called salvinorin A. The average concentration of salvinorin A in Salvia divinorum leaves is about 2.5 mg per gram. A moderate smoked dose of salvinorin A for a person of average sensitivity is 0.5 mg. Therefore, 200 mg (1/5 gram) of average-strength Salvia divinorum leaves contains enough salvinorin A to produce moderate effects in a person of average sensitivity. In practice however, one may need to use about twice this dose (i.e. 400 mg, or 2/5 gram), because some salvinorin A is probably decomposed during burning, some is lost in smoke that escapes during smoking, and some is not fully absorbed in the lungs and is thus lost upon exhaling.
Four hundred milligrams of Salvia divinorum leaf produces quite a lot of smoke, and it requires several large inhalations to consume it all. Because salvinorin A is rapidly metabolized in the body, it is essential that the full dose be ingested within a two to three minute period. It is also essential that the smoke is absorbed as efficiently as possible, otherwise much of it will be wasted. People vary in their ability to inhale and retain large amounts of smoke. Some people have no trouble obtaining strong effects from ordinary, non-enhanced leaves; others find it very difficult.
The potency of Salvia divinorum leaves is variable. Most of the samples that I have tested have a salvinorin A content between two and four milligrams per gram of dry leaf. I have however seen some samples that contained less than one milligram per gram. So far, no one has identified the specific factors that influence the concentration of salvinorin A in the leaves. Obviously, it is easier to obtain effects when using leaves of higher potency. When smoking leaves known to have a higher-than-average concentration of salvinorin A, it is important that you reduce the amount of leaf estimated per dose accordingly. When the potency of the leaves is unknown, you should always start with a conservative dose (no more than 1/8 gram), just in case it turns out that they are particularly potent. Please note that these dosage recommendations apply only to non-enhanced leaves. When using extract-enhanced leaves, the amount of leaf per dose will be reduced considerably. The specific dosage required depends both on the concentration of salvinorin A in the leaf and on the sensitivity of the person ingesting it. People vary in their sensitivity to salvinorin A. Some people are highly sensitive and have no difficulty obtaining a profound level of effects; others are extremely insensitive and require a dose several times higher than average.
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